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KMID : 0606320040200010029
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Journal of Phamacetical Sciences Sookmyung Women s University
2004 Volume.20 No. 1 p.29 ~ p.36
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A Nitric Oxide Synthase Inhibitor from Tussilago farfara
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Jeong Yeon-Su
Ryu Jae-Ha
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Abstract
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Nitric Oxide (NO), derived from L-arginine, is produced by two types of nitric oxide synthases (constitutive NOS: cNOS, inducible NOS: iNOS). The NO produced in large amounts by the iNOS is known to be responsible for the vasodilation and hypotension observed in septic shock and inflammation. The inhibitors of iNOS, thus, may be useful candidates for the treatment of inflammatory diseases accompanied by the overproduction of NO. The activity guided fractionation of the hexane soluble fraction obtained from the methanol extract of Tussilago farfara gave an inhibitory active compound of NO synthesis in LPS-activated macrophages (IC50 value was 8.9 μM). The structure of active compound was elucidated as 1a, 5a-bisacetoxy-8-angeloyloxy-3β, 4β-epoxybisabola-7(14), 10-dien-2-one by spectral analysis. This compound can be a useful candidate for the development of new drugs to treat endotoxemia and inflammation accompanied by the overproduction of NO.
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